منابع مشابه
When Triple Helix Unravels:
Cooperative research centers (CRCs) are a significant and growing “triple helix-based” vehicle for promoting cross sector collaboration, knowledge and technology transfer and ultimately innovation. Although there is a growing social science literature on these organizational structures, the management and “best practice” portion of this literature have tended to emphasize success stories and to...
متن کاملTriple Helix-Forming Oligonucleotide
Triple-helical DNA can be formed by oligonucleotides that bind as third strands of DNA in a sequencespecific manner in the major groove in homopurine/homopyrimidine stretches in duplex DNA. Such triple helix-forming oligonucleotides have been used to inhibit gene expression by blocking transcription factor access to promoter sites in transient expression assays. In an alternative approach to ge...
متن کاملThioamides in the collagen triple helix.
To probe noncovalent interactions within the collagen triple helix, backbone amides were replaced with a thioamide isostere. This subtle substitution is the first in the collagen backbone that does not compromise thermostability. A triple helix with a thioamide as a hydrogen bond donor was found to be more stable than triple helices assembled from isomeric thiopeptides.
متن کاملCan Synergy in Triple-Helix Relations be Quantified? A Review of the Development of the Triple-Helix Indicator
Triple-Helix arrangements of biand trilateral relations can be considered as adaptive ecosystems. During the last decade, we have further developed a Triple-Helix indicator of synergy as reduction of uncertainty in niches that can be shaped among three or more distributions. Reduction of uncertainty can be generated in correlations among distributions of relations, but this (next-order) effect ...
متن کامل(antisense/antigene/hybrid duplex/triple helix)
Deoxyribonucleic guanidine is a potential antisense agent that is generated via the replacement ofthe negative phosphodiester linkages ofDNA [-O-(POj)-0-O with positively-charged guanidinium (g) linkages [-NH--C(=NH2) -NH-]. A pentameric thymidyl deoxyribonucleic guanidine molecule [d(Tg)4T-azido] has been shown to base pair specifically to poly(rA) with an unprecedented affinity. Both double a...
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ژورنال
عنوان ژورنال: Nature
سال: 1992
ISSN: 0028-0836,1476-4687
DOI: 10.1038/355677a0